Bio Bench Advanced Bioreactor

Bio Bench Advanced Bioreactor
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Bio Bench Pro Module
Gas Mixing Module
Pump Module

Next Generation Bioreactors

  • Modular Bioreactors suitable for various vessels type and size ; re-usable glass autoclavable, SUB disposable and scalable to lab-pilot SIP in situ sterilizable systems for multi purpose fermentation and cell culture applications.
  • BIO BENCH Advanced Controller can handle and interchange Vessels solutions from 100mL up to 100 Litres working volume
  • The BIO BENCH ADVANCED is upgradable with almost an unlimited number of I/O that enable you to work single and parallel bioreactors. PRO Controller can manage up to 24 systems working simultaneously and independently.
  • Powerful SCADA Software BIOFLEX TM for multipurpose fermentations and cell cultures processes.

 

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  • Bio Bench is a new concept of Modular Bioreactors suitable for various vessels type and size ; re-usable glass autoclavable, SUB disposable and scalable to lab-pilot SIP in situ sterilizable systems for multi purpose fermentation and cell culture applications.
  • BBA ‘Bio Bench Advanced’ Bioreactors represent the latest advancements in mechanical, automation and software engineering applied to the bioprocess industry. Industrial standard technologies, high-flexibility, modularity, easy upgrades and replacements, guaranteed long term spare parts availability and after-sales service distinguish Solida Biotech from competition.
  • BIO BENCH Advanced Controller can handle and interchange other than 30 Vessels solutions available from 100mL up to 100 Litres working volume:
  • DJ double jacketed, working volume 100ml up to 20L
  • SJ single jacket, working volume 100ml up to 20L
  • SUB disposable, working volume from 250ml up to 75L
  • PBR photo-bioreactors, working volume 1L up to 30L
  • Air-Lift / Gas-Lift, working volume 1L up to 30L
  • SIP Lab-Pilot in situ sterilizable vessels, working volume from 1L up to 100L
  • X Custom fit solutions available on request
  • High Flexibility and Reliability via PLC automation and software platforms
  • Modularity and upgrades at any time thanks to our new concept design
  • Quality without compromise only certified materials are selected
  • Smart pH and D.O. probes allow monitoring of all sensor functions making substantial advantages in bioprocess monitoring and control
  • pH sensor empower fully integrated accuracy monitoring
  • Monitoring of all sensor functions, status of the sensor quality (glass resistance, reference resistance, checkref potential).
  • D.O. optical sensors demonstrate a number of substantial advantages because of a symbiosis of sensor and measurement amplifier- an smart sensor.
  • Variable or fix speed peristaltic pumps, autoclavable type in an embodiment, the present solution provides a new and improved liquid metering pump adapted for pumping sterile fluids and/or foodstuffs.
  • Eoon introduce onto his Bioreactors liquid metering pumps to avoid contamination problems caused by manual handling.
  • Complete documentation. IOQ, DQ and components traceability for GLP and cGMP
  • Service and Maintenance with a worldwide network
Specification Bio Bench Advanced
Agitation System Direct drive, mechanical or magnetically coupled drive
Stirrer speed (rpm) Standard range is 1 – 2000 rpm adjustable according to required configuration either bacterial, cell culture or both
Impellers Rushton, marine, pitched Blade, adjustable and removable type impellers. Special impellers are also available
Gas sparger Porous sparger, L-type sparger, Sinterized sparger, fixed or removable type
Gas overlay Available as option
Gas mixing Standard set-up include Air, O2, CO2 and N2 gas mixing station, Rotameters with precision control valve or TMFC mass flow controllers for automatic gas flow control, regulation and data recording up to 8 Rotameters and TMFC mass flow controller for each bioreactor
Peristaltic Pumps Standard set-up include 3 Easy-load peristaltic pumps for precise liquid addition. The system is upgradable with 2 additional variable speed peristaltic pumps for feeding and harvesting control. Up to 8 fix and variable speed peristaltic pumps for each bioreactor.
Exhaust gas Water cooled exhaust gas Condenser
Sampling Sanitary sampling system with Fixed height and Height adjustable sampling pipe including contained sampling bottles
Harvesting Harvest pipe and Dip tube Fixed height or Height adjustable
Liquid additions Triple or single inlet ports for chemicals additions (optional micro liquid injectors).
pH Optical or Digital pH sensors, 12mm, 19mm PG 13.5 Ingold fitting (220mm, 320mm, 420mm length). Intelligent Cascade Control with acid and alkali pumps and/or CO2 gas (Rotameters or TMFC mass flow controllers).
DO2 Optical or Digital DO sensor, 12mm, 19mm PG 13.5 Ingold fitting (220mm, 320mm, 420mm length) Intelligent Cascade Control with Air, O2, N2 (Rotameters or TMFC mass flow controllers), Agitation and Feeding Pumps
Temperature Pt-100 RDT probe. Automated Control of cooling and heating modules. Chiller is also available as optional
Foam Conductivity based foam sensor, high/low foam, height adjustable. Automated Control with anti foam addition pump or other actuators
Level Continuous level monitoring sensor, height adjustable. Automated Control with input and output pumps
Pressure Pressure sensor top plate mounted. Automated Control with modulating pressure valve combined with Gas inlet, Rotameters/TMFC, Agitation and other actuators.
Weight Load cells and Scales available. Automated Control with input and output pumps
Online sensors Integrated online Biomass sensor, Optical Density probes, Glucose sensor,CO2/O2/NH4/SO2 Gas Analyzer, pCO2 probe

conductivity, methanol/ethanol analyzers. Automated samplers. Software Control and integration via OPC interface

Photo-Bioreactors Special accessories for photo-synthetic  and photo trophic microorganisms, LED light set available in white, blue, red and other colours

 

Note: BIO BENCH ADVANCED innovative Modular concept enable to integrate an unlimited number of Sensors, Gas mixing and Pumps modules to maximise your Bioreactor flexibility and performances.

Key Competitive Advantages

  • Leading Master Controller technology for advanced data-logging and embedded monitoring applications.
  • Unlimited Series I/O modules for a custom analog input, analog output, digital I/O, counter/timer, and CAN measurement and logging system. Modules are available for a variety of sensor measurements.
  • PRO Advanced Controller for Single and Parallel Bioreactors and Fermentors.
  • PRO Controller can manage up to 24 systems working simultaneously and independently.
  • Inclusive Powerful SCADA Software BIOFLEX TM for multipurpose fermentations and cell cultures processes.
  • One Controller platform for glass autoclavable, SUB disposable and SIP stainless steel systems.
  • One Controller solution for a wide selections of Vessels from 75mL to 100L w/v.
  • Unlimited number of Modules integration for Single and Parallel Bioreactors and Fermentors.
  • Immediate modules replacement without downtime.
  • Industry standard Controller technology for faster scaling up and IndustrializationAdaptable Controller and Software for Custom fit projects.
  • Built-in Optical pH and Dissolved Oxygen sensor for improved accuracy and durability.
  • Integrated measurement of Online Sensors such like Biomass, Optical density, Gas Analyser, Glucose Analyser, Alchool Analyser, pCO2 Analyser, HPLC’s, Autosamplers and others.
  • Online 24/24h maintenance service and support with remote diagnostics.
STR Stirred tank Glass autoclavable Vessels
Total volume Working min. Working vol.
500mL / Single wall / Jacketed 75 mL 400 mL
750mL / Single wall / Jacketed 150 mL 600 mL
1L / Single wall / Jacketed 250 mL 800 mL
2L / Single wall / Jacketed 0,4 L 1,6 L
3L / Single wall / Jacketed 0,6L 2,5L
5L / Single wall / Jacketed 1,0 L 4,0 L
7L / Single wall / Jacketed 1,4 L 5,6 L
10L / Single wall / Jacketed 2,0 L 8,0 L
15L / Single wall / Jacketed 3,0 L 12,0 L
20L / Single wall / Jacketed 4,0 L 16,0 L
SUB Single use Disposable Vessels
Total volume Working min. Working vol.
250mL / Single wall / Jacketed 50 mL 200 mL
500mL / Single wall / Jacketed 75 mL 400 mL
1L / Single wall / Jacketed 250 mL 800 mL
2L / Single wall / Jacketed 0,4 L 1,6 L
3L / Single wall / Jacketed 0,6L 2,5L
6L / Single wall / Jacketed 1,2 L 5,0 L
10L / Single wall / Jacketed 2,0 L 8,0 L
15L / Single wall / Jacketed 3,0 L 12,0 L
20L / Single wall / Jacketed 4,0 L 16,0 L
30L / Single wall / Jacketed 6,0 L 25,0 L
50L / Single wall / Jacketed 10,0 L 40,0 L
75L / Single wall / Jacketed 15,0 L 65,0 L

Bio Bench Pro Module

ONE CONTROLLER , MANY SOLUTIONS

  • Controller and Software capabilities from Single to Parallel Bioreactors operations (24 units or more)
  • PLC ‘Programmable Automation Controller’ combined embedded Real time / FPGA  technology
  • HMI-PC  Touch Panel Interface with large color Screen 15”, 19” and 22” size available
  • Integrated BIOFLEX TM Software for Real time process monitoring, supervisory and remote control
  • Industry standard  Ethernet communication for BIOFLEX SCADA Software for simultaneous control of up to 32 systems  and IP network for remote monitoring and technical support assistance
  • Designed to give most configuration flexibility to perform complex functions or merely simple set-up
  • Modular design for unlimited integration of pumps, gas mixing, sensors and actuators in a single or parallel vessels
  • Controller compatible with a wide choose of 30 different interchangeable vessels; Glass autoclavable, SUB disposable, SIP/CIP  Stainless Steel and custom fit
  • Extensive working volume from 75mL to 100 Liters on a single control platform
  • Unique Motor drive for all vessels range with Direct mechanical agitator or Magnetic drive capable of clockwise or Counterclockwise rotation
  • Built-in Optical pH and Dissolved Oxygen sensor for improved accuracy and durability
  • Integration and Interconnectivity with external analyzers, devices, control units and software
  • Non volatile flash memory card for data savings, archive and back up
  • PAT and OPC compliance
  • IP 68, 22, 55 and 65 rated connections and protections for GLP and GMP classified environments.

Gas Mixing Module

  • Innovative Massflow controllers and Rotameters gradient insensitive, accurate temperature and pressure correction for high linearity measurement and control
  • Improved control valve reliable, reproducible, outstanding dynamic behavior
  • Multistage control loops to achieve enhanced dynamic behavior for precise Gas regulation
  • Up to 8 Thermal Mass flow controllers and Rotameters for a Single Bioreactor & Fermentor
  • Up to 192 Thermal Mass flow controllers and Rotameters for Parallel Bioreactors & Fermentors
  • Gas Mixing for Sparger and Overlay with combined or independent controlled actuators
  • Selectable accurate gas control flow rate for microbial and cell culture applications
  • Adaptable to your process, the control performance are adjusted to swiftly respond to setpoint changes, without overshoot.
  • Gases selectable from embedded database; Air, O2, CO2, N2, H2s, HN3 and other gases available for aerobic and anaerobic cultures
  • Automated Software cascade control for pH and DO regulation with Gas mixing
  • Normally Closed / Normally Opened control valve function, possibility of integrated shut-off valve
  • Upgraded electronics versatile flow control algorithms, embedded intelligence, reduced power consumption

Pump Module

  • Superior flow stability and metering accuracy, facilitating high-quality bioprocessing
  • Flexible and scalable, without changing contact materials or losing performance, ensuring the process remains controlled and repeatable at every scale
  • Driven to increase product quality, titer and cell viability, the non-contacting, gentle action of  BIO BENCH peristaltic pumps is the perfect solution for feeds and sampling duties.
  • Providing consistency and repeatability preventing process deviation/non-conformance, maintaining cGMP compliance.
  • Up to 8 Variable and Fix Speed Peristaltic Pumps for a Single Bioreactor & Fermentor
  • Up to 192 Variable and Fix Speed Peristaltic Pumps for Parallel Bioreactors & Fermentors
  • Pump rotation may be set clockwise or counter-clockwise, whichever is convenient.
  • Peristaltic pumps are self-priming and self-sealing against backflow, no valves required for inlet or  discharge lines
  • Selectable speed rate 0 – 150 rpm for controlled continuous flow
  • Four tube-holder positions to hold tubes sizes from 0.5 mm to 10 mm for various flow rates
  • Standard operating temperature -10°C to 50°C