BIO-SIP Lab Bioreactor

SIP-Lab
BIO SIP-CIP BIOREACTOR
BIO SIP-CIP BIOREACTOR_1

BIO-SIP Pilot In situ sterilizable industrial Bioreactors/Fermentors 3-50L

  • Laboratory scale Culture vessels are available in bacteriological or cell cultivation configurations in the following Standard Volumes (total litres): 1, 3, 5, 7 ,10 , 15 , 20, 30, 40, 50
  • Powerful SCADA Software to manage multiple bioreactors at the same
  • All systems are fully documented for cGMP usage and are supplied with an extensive documentation package to support validation.

 

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  • Solida Biotech offers a complete range of laboratory and pilot SIP in situ sterilizable bioreactors and fermenters. Innovative hardware and software technologies, Modular and Compact design. Pre-assembled SIP bioreactors packages or custom made solutions based on detailed customer requirements.
  • Laboratory scale Culture vessels are available in bacteriological or cell cultivation configurations in the following Standard Volumes (total litres): 1, 3, 5, 7 ,10 , 15 , 20, 30, 40, 50, (other volumes upon request)
  • The BIO-SIP Lab range is a direct scale-up from the lab scale autoclavable bioreactors BIO-BENCH series. The same Controller and Software platforms make eases scale-up and minimizes risks in process transfer to next level.
  • The contained footprint guarantees that the minimal amount of lab space is occupied by the system.
    All systems are fully documented for cGMP usage and are supplied with an extensive documentation package to support validation.
  • Applications include:
  1.   lab-scale fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
  2.  cell culture of mammalian, insect, and human cell lines
  3.  stem cell culture, vaccine, monoclonal antibody
  4.  renewable energies, biofuel/biopolymer R&D
  • Industrial design for easier scale up and technology transfer
  • PLC industry standard Controller meet a unique Modular design for more Flexibility and Expandability
  • Leading Master Controller with Interchangeable vessels from 20L to 500L scale
  • Powerful SCADA Software to manage multiple bioreactors at the same
  • Chosen of leading PLC and communication devices: Siemens, National Instruments, Allen Bradley or Delta V.
  • Fully automatic in-situ sterilization with integrated steam generators
  • CIP cleaning in place systems built in or as external device
  • Integration of Online Analyzers and Autosamplers for complete process control
  • Integration of Down-stream equipments
  • Quality without compromise only certified materials are selected
  • Digital pH and D.O. sensors enable real time monitoring and remote diagnostics making substantial advantages in bioprocess control
  • Gas mixing with integrated and automated TMFC Massflow controllers for cell culture and fermentation
  • Variable or fix speed peristaltic pumps,
  • Complete documentation. IOQ, DQ and components traceability conform to cGMP and GAMP guidelines
  • Service and Maintenance with a worldwide network
Specification BIO-SIP_Lab
Agitation System Direct drive, mechanical or magnetically coupled drive
Stirrer speed (rpm) Standard range is 1 – 2000 rpm adjustable according to required configuration either bacterial, cell culture or both
Impellers Rushton, marine, pitched Blade, adjustable and removable type impellers. Special impellers are also available
Gas sparger Porous sparger, L-type sparger, Sinterized sparger, fixed or removable type
Gas overlay Included as standard feature
Gas mixing Standard set-up include Air, O2, CO2 and n2 gas mixing station, our unit can hold up to 8 gasses. Standard set-up include Flowmeters with on/off automatic solenoid valve for gas flow regulation or massflow controllers for automatic gas flow control and data recording
Exhaust gas Water cooled exhaust gas Condenser
Sampling Sanitary sampling system with Fixed height or Height adjustable sampling pipe including contained sample bottles available with various volumes. DN Ingold sampling port or Retractable-fit type are available
Harvesting Harvest pipe and Dip tube Fixed height or Height adjustable
Liquid additions Triple or single inlet ports for chemicals additions (optional micro liquid injectors).
pH Optical or classic pH sensor, 12mm, 19mm or 25mm Ingold connectors, (various lenght). PLC and SCADA Software Control: via acid pump or CO2 gas (Flowmeter or mFC) in combination with alkali pump and/or other actuators.
DO2 Optical or classic DO sensor, 12mm, 19mm or 25mm Ingold connectors, (various lenght). PLC and SCADA Software Control: via or in combination with n2, Air, O2 (Flowmeter or automation mFC) and agitation or nutrient addition pump or other actuators
Temperature Pt-100 sensor in thermo well in top plate. PLC and SCADA Software Control: cooling and/or heating jacket via bioreactor wall or via internal heat exchanger, cooling via tap water or chilled water
Foam Height adjustable conductivity based foam and level sensor, High/low foam sensors are also available. PLC and SCADA Software Control: Anti foam addition pump or other actuators.
Level Height adjustable conductivity based level sensor. PLC and SCADA Software Control: pump for liquid addition or removal
Pressure Pressure sensor top plate mounted. PLC and SCADA Software Control: modulated pressure valve, combined with air inlet, Flowmeters/mFC, agitation and other actuators
Weight Load cells and balances are available. PLC and SCADA Software Control: pump for liquid addition or removal, chemostat or continuous mode.
Probes and sensors available Online Biomass probes, optical density sensors, CO2/O2/nH4/SO2 gas analyzer, pCO2 sensor, conductivity, methanol/ethanol analyzers. Automated samplers PLC and SCADA Software Control integrations, OPC compliance.
Certifications IQ, OQ, PQ protocols available Including full material traceability GLP and cGMP compliance. User and maintenance manuals are available in English, French, German, Spanish or Italian. Chinese, Indian, Russian and Japanese languages, on request.
After sales support Worldwide after sales net-work with skilled engineers support. Remote diagnostic control and Online assistance 24/24h available.
Key competitive advantages
  •  Parallel operation reduces development times
  • Modular design and interconnectivity with external devices allow individual solutions
  • Superior BIOFLEX TM control software support sophisticated process control, comprehensive data and information management and Design of Experiments (DoE)
  • Advanced process development with consideration of Quality by Design (QbD) standards