BIO-SIP Pilot Bioreactor

SIP_Pilot
Bio_SIP_Pilot
BIO SIP-CIP BIOREACTOR
BIO SIP-CIP BIOREACTORS_1

BIO-SIP Pilot In situ sterilizable industrial Bioreactors/Fermentors 20-500L

  • Pilot SIP in situ sterilizable bioreactors and fermenters for multi purpose applications in microbial, yeasts fermentations and a cell cultivation.
  • Pilot scale Culture vessels are available in bacteriological or cell cultivation configurations in the following Standard Volumes (total litres): 20, 30, 40, 50, 70, 80, 100, 130, 150, 200, 250, 300, 400, 500.
  • Powerful Controllers, Robust Industrial automation, Advanced Scada Software solutions

 

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  • Solida Biotech introduce State of the art Pilot SIP in situ sterilizable bioreactors and fermenters for multi purpose applications in microbial, yeasts fermentations and a cell cultivation.
  • Powerful Controllers, Robust Industrial automation, Advanced Scada Software solutions enhance your your small scale production or technology transfer to industrialization. Quality by design systems with compact footprint to minimize your lab space needs.
  • Solida unique Modular concept features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements as well as custom fit solutions.
  • Pilot scale Culture vessels are available in bacteriological or cell cultivation configurations in the following Standard Volumes (total litres): 20, 30, 40, 50, 70, 80, 100, 130, 150, 200, 250, 300, 400, 500, (other volumes upon request).
    • Applications include:
    1.   lab-scale fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
    2.  cell culture of mammalian, insect, and human cell lines
    3.  stem cell culture, vaccine, monoclonal antibody
    4.  renewable energies, biofuel/biopolymer R&D
  • Powerful industry rated HMI-PC control system with 19” or 22” TFT color touchscreen
  • Independent process control for up to 36 culture vessels with a combination of STR stirred tank glass vessels, SUB disposable vessels and SIP in situ sterilizable vessels
  • Measurement and Control of pH, pO2, Temperature, Foam, Level, Substrate addition, Gas Mixing, Agitation, Gravimetric Feed and Harvest Control, Constant Total Gas Flow Control, Vessel pressure, Redox and Turbidity
  • Up to 8 integrated peristaltic pumps with choices for fixed and analogue speed pumps for each bioreactor
  • Superior gas mixing with up to 8 Rotameter and Mass Flow Controller for each bioreactor
  • Easy on-site Supply Tower and Culture vessel upgrade
  • Choice of pre-configured systems or customize from an extensive list of options
  • Improved connectivity of utilities and probes
  • Easy upgrade of cell culture packages for multi-purpose use
  • Inclusive Supervisory Process control software
  • Validation support available, inclusive Logbook and 4-Level password protection
Specification BIO-SIP Pilot
Agitation System Direct drive, mechanical or magnetically coupled drive
Stirrer speed (rpm) Standard range is 1 – 2000 rpm adjustable according to required configuration either bacterial, cell culture or both
Impellers Rushton, marine, pitched Blade, adjustable and removable type impellers. Special impellers are also available
Gas sparger Porous sparger, L-type sparger, Sinterized sparger, fixed or removable type
Gas overlay Included as standard feature
Gas mixing Standard set-up include Air, O2, CO2 and n2 gas mixing station, our unit can hold up to 8 gasses. Standard set-up include Flowmeters with on/off automatic solenoid valve for gas flow regulation or massflow controllers for automatic gas flow control and data recording
Exhaust gas Water cooled exhaust gas Condenser
Sampling Sanitary sampling system with Fixed height or Height adjustable sampling pipe including contained sample bottles available with various volumes. DN Ingold sampling port or Retractable-fit type are available
Harvesting Harvest pipe and Dip tube Fixed height or Height adjustable
Liquid additions Triple or single inlet ports for chemicals additions (optional micro liquid injectors).
pH Optical or classic pH sensor, 12mm, 19mm or 25mm Ingold connectors, (various lenght). PLC and SCADA Software Control: via acid pump or CO2 gas (Flowmeter or mFC) in combination with alkali pump and/or other actuators.
DO2 Optical or classic DO sensor, 12mm, 19mm or 25mm Ingold connectors, (various lenght). PLC and SCADA Software Control: via or in combination with n2, Air, O2 (Flowmeter or automation mFC) and agitation or nutrient addition pump or other actuators
Temperature Pt-100 sensor in thermo well in top plate. PLC and SCADA Software Control: cooling and/or heating jacket via bioreactor wall or via internal heat exchanger, cooling via tap water or chilled water
Foam Height adjustable conductivity based foam and level sensor, High/low foam sensors are also available. PLC and SCADA Software Control: Anti foam addition pump or other actuators.
Level Height adjustable conductivity based level sensor. PLC and SCADA Software Control: pump for liquid addition or removal
Pressure Pressure sensor top plate mounted. PLC and SCADA Software Control: modulated pressure valve, combined with air inlet, Flowmeters/mFC, agitation and other actuators
Weight Load cells and balances are available. PLC and SCADA Software Control: pump for liquid addition or removal, chemostat or continuous mode.
Probes and sensors available Online Biomass probes, optical density sensors, CO2/O2/nH4/SO2 gas analyzer, pCO2 sensor, conductivity, methanol/ethanol analyzers. Automated samplers PLC and SCADA Software Control integrations, OPC compliance.
Certifications IQ, OQ, PQ protocols available Including full material traceability GLP and cGMP compliance. User and maintenance manuals are available in English, French, German, Spanish or Italian. Chinese, Indian, Russian and Japanese languages, on request.
After sales support Worldwide after sales net-work with skilled engineers support. Remote diagnostic control and Online assistance 24/24h available.
Key competitive advantages
  •  Parallel operation reduces development times
  • Modular design and interconnectivity with external devices allow individual solutions
  • Superior BIOFLEX TM control software support sophisticated process control, comprehensive data and information management and Design of Experiments (DoE)
  • Advanced process development with consideration of Quality by Design (QbD) standards