Parallel Bio Bench Advances

Parallele Bio Bench Advances
Parallel_ Bioreactors
Bio Bench Pro Module
Gas Mixing Module
Pump Module

Next Generation Bioreactors

  • The BIO BENCH PRO PARALLEL is a new generation of Fermentor| Bioreactor system, designed for meeting demanding requirements in both research and process development.
  • The BIO BENCH PRO PARALLEL consists of the local MAIN Control tower and can be configured with up to 36 bioreactors, each providing independent MODULES control of the respective culture vessel
  • Superior BIOFLEX TM control software support sophisticated process control, comprehensive data and information management and Design of Experiments (DoE) Advanced process development
  • The BIO BENCH PRO PARALLEL ideal for:
    – Industrial research
    – Process development
    – Up- and Down-scale experiments
    – Production process control
    – Small scale production

 

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  • The BIO BENCH PRO PARALLEL is a new generation of Fermentor| Bioreactor system, designed for meeting demanding requirements in both research and process development.
  • A newly engineered control system launches many of its well-proven design features into a new era, offering unprecedented advantages for process development laboratories around the world. Unrivaled for scale-down and scale-up modeling of various culture processes, the BIO BENCH PRO PARALLEL provides a new level of power and flexibility.
  • The BIO BENCH PRO PARALLEL consists of the local MAIN Control tower and can be configured with up to 36 bioreactors, each providing independent MODULES control of the respective culture vessel. The modular design of our systems offers flexible solutions for bioprocess development with mammalian, insect and human cells as well as stem cells in laboratory scale. Solida Biotech Parallel systems are characterized by parallel operation, accurate control and comprehensive information management.
  • They support the seamless integration of external analyzers (PAT), control units or software.
    Superior BIOFLEX TM control software support sophisticated process control, comprehensive data and information management and Design of Experiments (DoE)
  • Advanced process development with consideration of Quality by Design (QbD)  standards.
  • The BIO BENCH PRO PARALLEL ideal for:
    – Industrial research
    – Process development
    – Up- and Down-scale experiments
    – Production process control
    – Small scale production
  • MAIN Application:
    – Growth and production studies of microbial, mammalian, insect and plat cells
    – Culture media composition and optimization
    – Upscale migration i.e. Transition from shaking flasks
    – Downscale of production process for process optimization
    – Small scale protein and Mab expression
    – High cell density cultivation
  • The BIO BENCH PARALLEL Modules enable customized solutions for all requirements:
  • Continuously variable stirring speeds from 0 to 2.000 rpm
  • Temperature control with active heating and cooling options
  • Accurate control of pH, dissolved oxygen and level/foam
  • Parallel processing in batch, fed-batch and continuous operation by means of high precision speed controlled peristaltic pumps; perfusion feasible
  • Mass flow-controlled gassing with individual mixtures of air, N2, O2 and CO2
  • Exhaust analysis with direct calculation of oxygen and carbon dioxide transfer rates and respiratory quotient
  • Online analysers integration; Biomass sensors, pCO2 sensors, Alchool sensor, automated samplers.
  • Powerful industry rated HMI-PC control system with 19” or 22” TFT color touchscreen
  • Independent process control for up to 36 culture vessels with a combination of STR stirred tank glass vessels, SUB disposable vessels and SIP in situ sterilizable vessels
  • Measurement and Control opportunities of pH, pO2, Temperature, Foam, Level, Substrate addition, Gas Mixing, Agitation, Gravimetric Feed and Harvest Control, Constant Total Gas Flow Control, Vessel pressure, Redox, Biomass, Turbidity, Glucose and Gas Analysis.
  • Up to 8 integrated peristaltic pumps with choices for fixed and analogue speed pumps for each bioreactor
  • Superior gas mixing with up to 8 Rotameter and Mass Flow Controller for each bioreactor
  • Easy on-site Supply Tower and Culture vessel upgrade
  • Choice of pre-configured systems or customize from an extensive list of options
  • Improved connectivity of utilities and probes
  • Easy upgrade of cell culture packages for multi-purpose useInclusive Supervisory Process control softwareValidation support available, inclusive Logbook and 4-Level password protection
Specification Parallel Bio Bench Advances 
Agitation System Direct drive, mechanical or magnetically coupled drive
Stirrer speed (rpm) Standard range is 1 – 2000 rpm adjustable according to required configuration either bacterial, cell culture or both
Impellers Rushton, marine, pitched Blade, adjustable and removable type impellers. Special impellers are also available
Gas sparger Porous sparger, L-type sparger, Sinterized sparger, fixed or removable type
Gas overlay Included as standard feature
Gas mixing Standard set-up include Air, O2, CO2 and n2 gas mixing station, our unit can hold up to 8 gasses. Standard set-up include Flowmeters with on/off automatic solenoid valve for gas flow regulation or massflow controllers for automatic gas flow control and data recording
Exhaust gas Water cooled exhaust gas Condenser
Sampling Sanitary sampling system with Fixed height or Height adjustable sampling pipe including contained sample bottles available with various volumes
Harvesting Harvest pipe and Dip tube Fixed height or Height adjustable
Liquid additions Triple or single inlet ports for chemicals additions (optional micro liquid injectors).
pH Optical or classic pH sensor, 12mm, 19mm or 25mm Ingold connectors, (various lenght). PLC and SCADA Software Control: via acid pump or CO2 gas (Flowmeter or mFC) in combination with alkali pump and/or other actuators.
DO2 Optical or classic DO sensor, 12mm, 19mm or 25mm Ingold connectors, (various lenght). PLC and SCADA Software Control: via or in combination with n2, Air, O2 (Flowmeter or automation mFC) and agitation or nutrient addition pump or other actuators
Temperature Pt-100 sensor in thermo well in top plate. PLC and SCADA Software Control: cooling and/or heating jacket via bioreactor wall or via internal heat exchanger, cooling via tap water or chilled water
Foam Height adjustable conductivity based foam and level sensor, High/low foam sensors are also available. PLC and SCADA Software Control: Anti foam addition pump or other actuators.
Level Height adjustable conductivity based level sensor. PLC and SCADA Software Control: pump for liquid addition or removal
Pressure Pressure sensor top plate mounted. PLC and SCADA Software Control: modulated pressure valve, combined with air inlet, Flowmeters/mFC, agitation and other actuators
Weight Load cells and balances are available. PLC and SCADA Software Control: pump for liquid addition or removal
Probes and sensors available Online Biomass probes, optical density sensors, CO2/O2/nH4/SO2 gas analyzer, pCO2 sensor, conductivity, methanol/ethanol analyzers. Automated samplers PLC and SCADA Software Control integrations, OPC compliance.
Photo-Bioreactors Special accessories for photo syntetic and photo trophic microorganisms, variable lED light set and other.

Key Competitive Advantages

  • Leading Master Controller technology for advanced data-logging and embedded monitoring applications.
  • Unlimited Series I/O modules for a custom analog input, analog output, digital I/O, counter/timer, and CAN measurement and logging system. Modules are available for a variety of sensor measurements.
  • PRO Advanced Controller for Single and Parallel Bioreactors and Fermentors.
  • PRO Controller can manage up to 24 systems working simultaneously and independently.
  • Inclusive Powerful SCADA Software BIOFLEX TM for multipurpose fermentations and cell cultures processes.
  • One Controller platform for glass autoclavable, SUB disposable and SIP stainless steel systems.
  • One Controller solution for a wide selections of Vessels from 75mL to 100L w/v.
  • Unlimited number of Modules integration for Single and Parallel Bioreactors and Fermentors.
  • Immediate modules replacement without downtime.
  • Industry standard Controller technology for faster scaling up and IndustrializationAdaptable Controller and Software for Custom fit projects.
  • Built-in Optical pH and Dissolved Oxygen sensor for improved accuracy and durability.
  • Integrated measurement of Online Sensors such like Biomass, Optical density, Gas Analyser, Glucose Analyser, Alchool Analyser, pCO2 Analyser, HPLC’s, Autosamplers and others.
  • Online 24/24h maintenance service and support with remote diagnostics.
Total volume Working min. Working vol.
1L / Single wall / Jacketed 0,2 0,8
2L / Single wall / Jacketed 0,4 1,6
3L / Single wall / Jacketed 0,6 2,4
5L / Single wall / Jacketed 1,0 4,0
7L / Single wall / Jacketed 1,4 5,6
10L / Single wall / Jacketed 2,0 8,0
15L / Single wall / Jacketed 3,0 12,0
20L / Single wall / Jacketed 4,0 16,0

Bio Bench Pro Module

ONE CONTROLLER , MANY SOLUTIONS

  • Controller and Software capabilities from Single to Parallel Bioreactors operations (24 units or more)
  • PLC ‘Programmable Automation Controller’ combined embedded Real time / FPGA  technology
  • HMI-PC  Touch Panel Interface with large color Screen 15”, 19” and 22” size available
  • Integrated BIOFLEX TM Software for Real time process monitoring, supervisory and remote control
  • Industry standard  Ethernet communication for BIOFLEX SCADA Software for simultaneous control of up to 32 systems  and IP network for remote monitoring and technical support assistance
  • Designed to give most configuration flexibility to perform complex functions or merely simple set-up
  • Modular design for unlimited integration of pumps, gas mixing, sensors and actuators in a single or parallel vessels
  • Controller compatible with a wide choose of 30 different interchangeable vessels; Glass autoclavable, SUB disposable, SIP/CIP  Stainless Steel and custom fit
  • Extensive working volume from 75mL to 100 Liters on a single control platform
  • Unique Motor drive for all vessels range with Direct mechanical agitator or Magnetic drive capable of clockwise or Counterclockwise rotation
  • Built-in Optical pH and Dissolved Oxygen sensor for improved accuracy and durability
  • Integration and Interconnectivity with external analyzers, devices, control units and software
  • Non volatile flash memory card for data savings, archive and back up
  • PAT and OPC compliance
  • IP 68, 22, 55 and 65 rated connections and protections for GLP and GMP classified environments.

Gas Mixing Module

  • Innovative Massflow controllers and Rotameters gradient insensitive, accurate temperature and pressure correction for high linearity measurement and control
  • Improved control valve reliable, reproducible, outstanding dynamic behavior
  • Multistage control loops to achieve enhanced dynamic behavior for precise Gas regulation
  • Up to 8 Thermal Mass flow controllers and Rotameters for a Single Bioreactor & Fermentor
  • Up to 192 Thermal Mass flow controllers and Rotameters for Parallel Bioreactors & Fermentors
  • Gas Mixing for Sparger and Overlay with combined or independent controlled actuators
  • Selectable accurate gas control flow rate for microbial and cell culture applications
  • Adaptable to your process, the control performance are adjusted to swiftly respond to setpoint changes, without overshoot.
  • Gases selectable from embedded database; Air, O2, CO2, N2, H2s, HN3 and other gases available for aerobic and anaerobic cultures
  • Automated Software cascade control for pH and DO regulation with Gas mixing
  • Normally Closed / Normally Opened control valve function, possibility of integrated shut-off valve
  • Upgraded electronics versatile flow control algorithms, embedded intelligence, reduced power consumption

Pump Module

  • Superior flow stability and metering accuracy, facilitating high-quality bioprocessing
  • Flexible and scalable, without changing contact materials or losing performance, ensuring the process remains controlled and repeatable at every scale
  • Driven to increase product quality, titer and cell viability, the non-contacting, gentle action of  BIO BENCH peristaltic pumps is the perfect solution for feeds and sampling duties.
  • Providing consistency and repeatability preventing process deviation/non-conformance, maintaining cGMP compliance.
  • Up to 8 Variable and Fix Speed Peristaltic Pumps for a Single Bioreactor & Fermentor
  • Up to 192 Variable and Fix Speed Peristaltic Pumps for Parallel Bioreactors & Fermentors
  • Pump rotation may be set clockwise or counter-clockwise, whichever is convenient.
  • Peristaltic pumps are self-priming and self-sealing against backflow, no valves required for inlet or  discharge lines
  • Selectable speed rate 0 – 150 rpm for controlled continuous flow
  • Four tube-holder positions to hold tubes sizes from 0.5 mm to 10 mm for various flow rates
  • Standard operating temperature -10°C to 50°C