SIP Industrial Bioreactor

SIP Industrial
BIO SIP-CIP BIOREACTOR
BIO SIP-CIP BIOREACTOR-1

SIP Industrial 500L-50m3 Bioreactors

  • Solida-SIP compact Laboratory and Pilot Stainless Steel in situ sterilizable Bioreactors & Fermenters with PLC automation & Software system.
  • Culture vessels are available in bacteriological or cell cultivation configurations in the following Standard Volumes (total litres): 3, 5, 7 ,10 , 15 , 20, 30, 40, 50, 75, 100, 150, 200, 300, 400, 500L (other volumes upon request).
  • Powerful Controllers, Robust Industrial automation, Advanced Scada Software solutions

 

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  • Next Generation Bioreactors
    Solida Biotech team with over 20 years experience in bioreactors engineer and bioprocess technologies has realised a complete range of laboratory and pilot SIP in situ sterilizable bioreactors and fermenters.
    Solida Biotech offer pre-assembled SIP bioreactors packages or custom made solutions based on detailed customer requirements.

    Solida-SIP compact Laboratory and Pilot Stainless Steel in situ sterilizable Bioreactors & Fermenters with PLC automation & Software system.
    Culture vessels are available in bacteriological or cell cultivation configurations in the following Standard Volumes (total litres):
    3, 5, 7 ,10 , 15 , 20, 30, 40, 50, 75, 100, 150, 200, 300, 400, 500L (other volumes upon request).

  • Reduce lab space and energy consumption
  • High Flexibility and Reliability via PLC automation and software platforms
  • Chosen of leading PLC and communication devices: Siemens, Allen Bradley, Schneiders Electric, Mitsubishi, Delta V.
  • Modularity and upgrades at any time thanks to our new concept design
  • Quality without compromise only certified materials are selected
  • Smart pH and D.O. probes allow monitoring of all sensor functions making substantial advantages in bioprocess monitoring and control
  • pH sensor empower fully integrated accuracy monitoring
  • Monitoring of sensor quality (glass resistance, reference resistance, Checkref potential).
  • D.O. optical sensors demonstrate a number of substantial advantages because of a symbiosis of sensor and measurement amplifier- an smart sensor.
  • Variable or fix speed peristaltic pumps, autoclavable type
  • Complete documentation. IOQ, DQ and components traceability for GLP and cGMP
  • Service and Maintenance with a worldwide network
Specification SIP Industrial
Agitation System Direct drive, mechanical or magnetically coupled drive
Stirrer speed (rpm) Standard range is 1 – 2000 rpm adjustable according to required configuration either bacterial, cell culture or both
Impellers Rushton, marine, pitched Blade, adjustable and removable type impellers. Special impellers are also available
Gas sparger Porous sparger, L-type sparger, Sinterized sparger, fixed or removable type
Gas overlay Included as standard feature
Gas mixing Standard set-up include Air, O2, CO2 and n2 gas mixing station, our unit can hold up to 8 gasses. Standard set-up include Flowmeters with on/off automatic solenoid valve for gas flow regulation or massflow controllers for automatic gas flow control and data recording
Exhaust gas Water cooled exhaust gas Condenser
Sampling Sanitary sampling system with Fixed height or Height adjustable sampling pipe including contained sample bottles available with various volumes. DN Ingold sampling port or Retractable-fit type are available
Harvesting Harvest pipe and Dip tube Fixed height or Height adjustable
Liquid additions Triple or single inlet ports for chemicals additions (optional micro liquid injectors).
pH Optical or classic pH sensor, 12mm, 19mm or 25mm Ingold connectors, (various lenght). PLC and SCADA Software Control: via acid pump or CO2 gas (Flowmeter or mFC) in combination with alkali pump and/or other actuators.
DO2 Optical or classic DO sensor, 12mm, 19mm or 25mm Ingold connectors, (various lenght). PLC and SCADA Software Control: via or in combination with n2, Air, O2 (Flowmeter or automation mFC) and agitation or nutrient addition pump or other actuators
Temperature Pt-100 sensor in thermo well in top plate. PLC and SCADA Software Control: cooling and/or heating jacket via bioreactor wall or via internal heat exchanger, cooling via tap water or chilled water
Foam Height adjustable conductivity based foam and level sensor, High/low foam sensors are also available. PLC and SCADA Software Control: Anti foam addition pump or other actuators.
Level Height adjustable conductivity based level sensor. PLC and SCADA Software Control: pump for liquid addition or removal
Pressure Pressure sensor top plate mounted. PLC and SCADA Software Control: modulated pressure valve, combined with air inlet, Flowmeters/mFC, agitation and other actuators
Weight Load cells and balances are available. PLC and SCADA Software Control: pump for liquid addition or removal, chemostat or continuous mode.
Probes and sensors available Online Biomass probes, optical density sensors, CO2/O2/nH4/SO2 gas analyzer, pCO2 sensor, conductivity, methanol/ethanol analyzers. Automated samplers PLC and SCADA Software Control integrations, OPC compliance.
Certifications IQ, OQ, PQ protocols available Including full material traceability GLP and cGMP compliance. User and maintenance manuals are available in English, French, German, Spanish or Italian. Chinese, Indian, Russian and Japanese languages, on request.
After sales support Worldwide after sales net-work with skilled engineers support. Remote diagnostic control and Online assistance 24/24h available.
Key competitive advantages
  • Leading Master Controller technology for advanced data-logging and embedded monitoring applications.
  • Unlimited Series I/O modules for a custom analog input, analog output, digital I/O, counter/timer, and CAN measurement and logging system. Modules are available for a variety of sensor measurements.
  • PRO Advanced Controller for Single and Parallel Bioreactors and Fermentors.
  • PRO Controller can manage up to 24 systems working simultaneously and independently.
  • Inclusive Powerful SCADA Software BIOFLEX TM for multipurpose fermentations and cell cultures processes.
  • One Controller platform for glass autoclavable, SUB disposable and SIP stainless steel systems.
  • One Controller solution for a wide selections of Vessels from 75mL to 100L w/v.
  • Unlimited number of Modules integration for Single and Parallel Bioreactors and Fermentors.
  • Immediate modules replacement without downtime.
  • Industry standard Controller technology for faster scaling up and IndustrializationAdaptable Controller and Software for Custom fit projects.
  • Built-in Optical pH and Dissolved Oxygen sensor for improved accuracy and durability.
  • Integrated measurement of Online Sensors such like Biomass, Optical density, Gas Analyser, Glucose Analyser, Alchool Analyser, pCO2 Analyser, HPLC’s, Autosamplers and others.
  • Online 24/24h maintenance service and support with remote diagnostics.